PhenolAcTwin

Enhancing Research and Innovation Capacity of TUBITAK MRC Food Institute

on Dietary Polyphenols and Bioavailability/Bioefficacy

(Grant Agreement no: 951994)

PhenolAcTwin is an EU granted project under H2020-WIDESPREAD-2018-2020 call. The main objective of PhenolAcTwin is to enhance the research and innovation capacity of TUBITAK MRC Food Institute on dietary polyphenols focusing on their bioavailability and bioefficacy via networking with CSIC, QIB, and INRAE. Key scientific aspects of PhenolAcTwin are: molecular identification of dietary polyphenols, bioavailability and biological activity evaluation of dietary polyphenols, in vivo-in vitro analysis, metabolomics and cardiovascular protective effects of dietary polyphenols.

Defined activities of PhenolAcTwin such as; exchange of young researchers, summer schools, expert visits, trainings, conferences, and seminars will help young researchers to enhance the research and innovation capacity, as well as the research profile. PhenolAcTwin will provide mutual benefit to collaborators in the areas of polyphenols, bioavailability and bioefficacy through project activities. This will maximize the impact by enabling the stakeholders (scientist, industry, including SMEs) to be better able to innovate with the availability of new tools, technologies and knowledge. By participating the project activities, food industry will benefit in all aspects of the development and production of innovative healthy food products.



Characterization of

Dietary Polyphenols

▪︎ Extraction techniques of polyphenols

▪︎ Identification of polyphenols with mass spectroscopy

▪︎ Identification of polyphenols metabolites and catabolites

▪︎ Nutritional metabolomics





 Biological Activity Evaluation of

Dietary Polyphenols

▪︎ In vitro (cell cultures) and in vivo (animal models and clinical studies)

▪︎ Bioavailability and metabolism

▪︎ Polyphenol metabolites and catabolites

▪︎ Phytochemicals and their metabolites on human gene expression and microbiota interaction





Cardiovascular Protective Effects of

Dietary Polyphenols

▪︎ Clinical trial design

▪︎ Bioefficacy of polyphenols

▪︎ True exposure of individuals to polyphenols

▪︎ From cell mechanistic studies to human trials

▪︎ "Omics" (metabolomics, transcriptomics, proteomics) technologies